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الرئيسية / رائد عياد الحربي

رائد عياد الحربي

الثلاثاء _14 _مايو _2013

رائد عياد الحربي
دكتوراه
طب - علم أمراض الدم
University of Surrey

مجال التميز

تميز دراسي وبحثي 

 

 

البحوث المنشورة

 

البحث:

 

عنوان البحث:

The role of HOX genes in normal hematopoiesis and acute leukemia

رابط إلى البحث:

Link 

تاريخ النشر:

April 2013

موجز عن البحث:

The homeobox (HOX) genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and, subsequently, in a number of adult processes including hematopoiesis. The dysregulation of HOX genes is associated with a number of malignancies including acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), where they have been shown to support the immortalization of leukemic cells both as chimeric partners in fusion genes and when overexpressed in their wild-type form. This review covers our current understanding of the role of HOX genes in normal hematopoiesis, AML and ALL, with particular emphasis on the similarities and differences of HOX function in these contexts, their hematopoietic downstream gene targets and implications for therapy.

 

 

المؤتمرات العلمية:

 

المؤتمر (1):

 

عنوان المؤتمر:

   6th Saudi Scientific International conference

تاريخ الإنعقاد:

11-14/10/2012

بلد ومكان الإنعقاد:

UK

طبيعة المشاركة:

Poster

عنوان المشاركة:

Triggering apoptosis of AML cells by blocking HOX-PBX dimer

الملخص:

Acute myeloid leukaemia (AML) is a disorder characterised by the accumulation of blast cells or progenitors of one of several non-lymphoid haematopoietic cell lineages. AML is classified into two types: primary ” de novo mutations”, and secondary, which follows myelodysplasia, chronic myeloid leukaemia or previous treatment with chemotherapy. HOX genes are overexpressed in both AML and other cancers. This overexpression is associated with an intermediate/ unfavourable cytogenetic subset of AML. Although HOX overexpression is a common feature of NK-AML, conventional knock out methods have failed to fully evaluate their functions due to their functional redundancy. We have applied an alternative approach by using a synthetic peptide called HXR9 to antagonise the interaction between HOX proteins and their cofactor PBX, which interacts with HOX proteins in groups 1-9.

المؤتمر (2):

 

عنوان المؤتمر:

2nd World Congress Controversies in Hematology (COHEM)

تاريخ الإنعقاد:

September 2012

بلد ومكان الإنعقاد:

Barcelona, Spain

طبيعة المشاركة:

Poster

المؤتمر (3):

 

عنوان المؤتمر:

Apoptosis and Cancer

تاريخ الإنعقاد:

June 2012

بلد ومكان الإنعقاد:

Cambridge, UK

طبيعة المشاركة:

Poster

عنوان المشاركة:

Could HOX-PBX interaction be a novel therapy for AML? 

الملخص:

The HOX genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and, subsequently, in a number of adult processes including hematopeisis. The dys-regulation of HOX genes is associated with a number of malignancies including acute myeloid leukemia (AML), where they have been shown to support the immortalization of myeloid precursor cells both as chimeric partners in fusion genes and when over-expressed in their wild type form. Here we measured the expression of HOX genes in AML derived cell lines which included HL-60, KG-1 and HEL92.1.7, derived from de novo AML, and KU812F and K562 from secondary AML. In addition, we evaluated their expression and function in normal and primary AML PBMCs.

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