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مجال التميز
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تميز
دراسي وبحثي
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البحوث المنشورة
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البحث:
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عنوان البحث:
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The role of HOX
genes in normal hematopoiesis and acute leukemia
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رابط إلى البحث:
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Link
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تاريخ النشر:
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April 2013
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موجز عن البحث:
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The homeobox (HOX) genes are a highly conserved
family of homeodomain-containing transcription factors that specify cell
identity in early development and, subsequently, in a number of adult
processes including hematopoiesis. The dysregulation of HOX genes is associated
with a number of malignancies including acute myeloid leukemia (AML) and
acute lymphoid leukemia (ALL), where they have been shown to support the
immortalization of leukemic cells both as chimeric partners in fusion genes
and when overexpressed in their wild-type form. This review covers our
current understanding of the role of HOX genes in normal hematopoiesis, AML
and ALL, with particular emphasis on the similarities and differences of HOX
function in these contexts, their hematopoietic downstream gene targets and
implications for therapy.
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المؤتمرات العلمية:
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المؤتمر (1):
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عنوان المؤتمر:
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6th
Saudi Scientific International conference
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تاريخ الإنعقاد:
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11-14/10/2012
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بلد
ومكان الإنعقاد:
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UK
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طبيعة المشاركة:
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Poster
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عنوان
المشاركة:
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Triggering apoptosis of AML cells by blocking HOX-PBX dimer
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الملخص:
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Acute myeloid leukaemia (AML) is a
disorder characterised by the accumulation of blast cells or progenitors of
one of several non-lymphoid haematopoietic cell lineages. AML is classified into
two types: primary ” de novo mutations”, and secondary, which
follows myelodysplasia, chronic myeloid leukaemia or previous treatment with
chemotherapy. HOX genes are overexpressed in both AML and other cancers. This
overexpression is associated with an intermediate/ unfavourable cytogenetic
subset of AML. Although HOX overexpression is a common feature of NK-AML, conventional
knock out methods have failed to fully evaluate their functions due to their
functional redundancy. We have applied an alternative approach by using a
synthetic peptide called HXR9 to antagonise the interaction between HOX
proteins and their cofactor PBX, which interacts with HOX proteins in groups
1-9.
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المؤتمر (2):
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عنوان المؤتمر:
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2nd World Congress
Controversies in Hematology (COHEM)
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تاريخ الإنعقاد:
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September
2012
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بلد
ومكان الإنعقاد:
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Barcelona,
Spain
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طبيعة المشاركة:
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Poster
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المؤتمر (3):
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عنوان المؤتمر:
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Apoptosis
and Cancer
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تاريخ الإنعقاد:
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June 2012
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بلد
ومكان الإنعقاد:
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Cambridge,
UK
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طبيعة المشاركة:
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Poster
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عنوان المشاركة:
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Could HOX-PBX
interaction be a novel therapy for AML?
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الملخص:
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The HOX
genes are a highly conserved family of homeodomain-containing transcription
factors that specify cell identity in early development and, subsequently, in
a number of adult processes including hematopeisis. The dys-regulation of HOX genes is associated with a number
of malignancies including acute myeloid leukemia (AML), where they have been
shown to support the immortalization of myeloid precursor cells both as
chimeric partners in fusion genes and when over-expressed in their wild type
form. Here we measured the expression of HOX genes in AML derived cell lines
which included HL-60, KG-1 and HEL92.1.7, derived from de novo AML,
and KU812F and K562 from secondary AML. In addition, we evaluated their
expression and function in normal and primary AML PBMCs.
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