مجال
التميز
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تميز دراسي وبحثي
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البحوث المنشورة
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البحث (1):
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عنوان البحث:
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The incidence rate of female breast cancer
in Saudi Arabia: an observational descriptive epidemiological analysis of
data from Saudi Cancer Registry 2001–2008
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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October 2013
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موجز عن البحث:
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Background: This study
presents descriptive epidemiological data related to breast cancer cases
diagnosed from 2001 to 2008 among Saudi women, including the frequency and
percentage of cases, the crude incidence rate (CIR), and the age-standardized
incidence rate (ASIR), adjusted by the region and year of diagnosis.
Methods: This is a
retrospective descriptive epidemiological study of all Saudi female breast
cancer cases from 2001 to 2008. The statistical analyses were conducted using
descriptive statistics, a linear regression model, and analysis of variance
with the Statistical Package for the Social Sciences version 20 (IBM
Corporation, Armonk, NY, USA).
Results: A total of
6,922 female breast cancer cases were recorded in the Saudi Cancer Registry
from 2001 to 2008. The highest overall percentages (38.6% and 31.2%) of
female breast cancer cases were documented in women who were 30–44 and 45–59
years of age, respectively. The eastern region of Saudi Arabia had the
highest overall ASIR, at 26.6 per 100,000 women, followed by Riyadh at 20.5
and Makkah at 19.4. Jazan, Baha, and Asir had the lowest average ASIRs, at
4.8, 6.1, and 7.3 per 100,000 women, respectively. The region of Jouf (24.2%;
CIR 11.2, ASIR 17.2) had the highest changes in CIR and ASIR from 2001 to
2008. While Qassim, Jazan and Tabuk recorded down-trending rates with
negative values.
Conclusion: There
was a significant increase in the CIRs and ASIRs for female breast cancer
between 2001 and 2008. The majority of breast cancer cases occurred among
younger women. The region of Jouf had the greatest significant differences of
CIR and ASIR during 2001 to 2008. Jazan, Baha, and Najran had the lowest
average CIRs and ASIRs of female breast cancer, whereas the linear trend
upward is a concern in certain regions, such as the eastern region, Makkah,
and Riyadh. However, further analytical epidemiological research is needed to
identify the potential risk factors involved in the increase in the
prevalence of breast cancer among Saudi women.
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البحث (2):
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عنوان البحث:
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The incidence rate
of prostate cancer in Saudi Arabia: an observational descriptive
epidemiological analysis of data from the Saudi Cancer Registry 2001-2008
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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November 2013
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موجز عن البحث:
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Background: This study presents descriptive epidemiological
data related to prostate cancer cases diagnosed from 2001 to 2008 among Saudi
men, including the frequency and percentage of cases, the crude incidence
rate (CIR) and the age-standardised incidence rate (ASIR) adjusted by region
and year of diagnosis.
Methods: This is a retrospective descriptive epidemiological
analysis of all Saudi prostate cancer cases recorded in the Saudi Cancer
Registry (SCR) between January 2001 and December 2008. Statistical analyses
were conducted using descriptive statistics, the Poisson regression model, a
simple linear regression model and analysis of variance with the Statistical
Package for the Social Sciences version 20.0 (SPSS).
Results: A total of 1739 cases were registered in the SCR
between January 2001 and December 2008. The eastern region of Saudi Arabia
had the highest overall ASIR at 10.1 per 100,000 men, followed by Riyadh at
7.1 and Makkah at 5.2, while Jizan and Najran had the lowest average ASIRs at
1.4 and at 2.0, respectively. The Poisson regression model for the region of
Jizan shows that the incidence rate ratio (IRR) was significantly higher (p
< 0.001); for the regions of Riyadh at 3.43 times (95% CI, 3.13–3.73),
followed by Makkah at 2.56 (95% CI, 2.38–2.74) and the eastern province at
1.93 (95% CI, 1.64–2.23). The annual prediction of the CIR of prostate cancer
in Saudi Arabia could be defined by the equation 1.53 + (0.094 · Years), and
the prediction of the ASIR could be defined by the equation 2.98 + (0.182 ·
Years).
Conclusion: There was a steady increase in the CIRs and ASIRs
for prostate cancer between 2001 and 2008. The eastern region, Riyadh and
Makkah had the highest overall ASIR in Saudi Arabia. Further effective
screening programmes and active treatment measures are needed to control
prostate cancer disease among Saudi men.
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البحث (3):
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عنوان البحث:
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The incidence rate of corpus uteri cancer
among females in Saudi Arabia: an observational descriptive epidemiological
analysis of data from Saudi Cancer Registry 2001–2008
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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Jan 2014
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موجز عن البحث:
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Background: The present
study reviews the epidemiological data on corpus uteri cancer among Saudi
women, including its frequency, crude incidence rate, and age-standardized
incidence rate (ASIR), adjusted by region and year of diagnosis.
Methods: A
retrospective, descriptive epidemiological analysis was conducted of all the
corpus uteri cancer cases recorded in the Saudi Cancer Registry between
January 2001 and December 2008. The statistical analyses were performed using
descriptive statistics, analysis of variance, Poisson regression, and a
simple linear model.
Results: A total of
1,060 corpus uteri cancer cases were included. Women aged 60–74 years of age
were most affected by the disease. The region of Riyadh in Saudi Arabia had
the highest overall ASIR, at 4.4 cases per 100,000 female patients, followed
by the eastern region, at 4.2, and Makkah, at 3.7. Jazan, Najran, and Qassim
had the lowest average ASIRs, ranging from 0.8 to 1.4. A Poisson regression
model using Jazan as the reference revealed that the corpus uteri cancer
incidence rate ratio was significantly higher for the regions of Makkah, at
16.5 times (95% confidence interval [CI]: 8.0–23.0), followed by Riyadh, at
16.0 times (95% CI: 9.0–22.0), and the eastern region, at 9.9 times (95% CI:
5.6–17.6). The northern region experienced the highest changes in ASIRs of
corpus uteri cancer among female Saudi patients between 2001 and 2008.
Conclusion: There was a
slight increase in the crude incidence rates and ASIRs for corpus uteri
cancer in Saudi Arabia between 2001 and 2008. Older Saudi women were most
affected by the disease. Riyadh, the eastern region, and Makkah had the
highest overall disease ASIRs and incidence rate ratios, while Jazan, Najran,
and Qassim had the lowest rates. Finally, the northern region experienced the
greatest changes in ASIR during the studied period. Further analytical
studies are necessary to determine potential risk factors of corpus uteri
cancer among female Saudi patients.
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البحث (4):
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عنوان البحث:
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Incidence
rate of ovarian cancer cases in Saudi Arabia: an observational descriptive
epidemiological analysis of data from Saudi Cancer Registry 2001–2008
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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Jun
2014
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موجز عن البحث:
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Purpose: This study
provides descriptive epidemiological data, such as the percentage of cases
diagnosed, crude incidence rate (CIR), and age-standardized incidence rate
(ASIR) of ovarian cancer in Saudi Arabia from 2001–2008.
Patients
and methods: A
retrospective descriptive epidemiological analysis of all ovarian cancer
cases recorded in the Saudi Cancer Registry (SCR) from January 2001–December
2008 was performed. The data were analyzed using descriptive statistics,
analysis of variance tests, Poisson regression, and simple linear modeling.
Results: A total of
991 ovarian cancer cases were recorded in the SCR from January 2001–De¬cember
2008. The region of Riyadh had the highest overall ASIR at 3.3 cases per
100,000 women, followed by the Jouf and Asir regions at 3.13 and 2.96 cases
per 100,000 women. However, Hail and Jazan had the lowest rates at 1.4 and
0.6 cases per 100,000 women, respectively. Compared to Jazan, the incidence
rate ratio for the number of ovarian cancer cases was significantly higher
(P,0.001) in the Makkah region at 6.4 (95% confidence interval [CI]:
4.13–9.83), followed by Riyadh at 6.3 (95% CI: 4.10–9.82), and the eastern
region of Saudi Arabia at 4.52 (95% CI: 2.93–6.98). The predicted annual CIR
and ASIR for ovarian cancer in Saudi Arabia could be defined by the equations
0.9 + (0.07× years) and 1.71 + (0.09× years), respectively.
Conclusion: We observed
a slight increase in the CIRs and ASIRs for ovarian cancer in Saudi Arabia
from 2001–2008. Riyadh, Jouf, and Asir had the highest overall ASIR, while
Jazan and Hail had the lowest rates. Makkah, Riyadh, and the eastern region
of Saudi Arabia had the high¬est incidence rate ratio for the number of
ovarian cancer cases. Further analytical studies are required to determine the
potential risk factors of ovarian cancer among Saudi women.
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البحث (5):
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عنوان البحث:
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Incidence rate of
non-Hodgkin’s lymphomas among males in Saudi Arabia: an observational
descriptive epidemiological analysis of data from the Saudi Cancer Registry, 2001
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رابط إلى البحث:
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تاريخ النشر:
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Jun 2014
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موجز عن البحث:
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Background: This study describes epidemiological data of
non-Hodgkin’s lymphoma (NHL) diagnosed from 2001 to 2008 among Saudi men.
Materials and
methods: Retrospective data from all NHL cancer cases among
Saudi men recorded in the Saudi Cancer Registry (SCR) between January 2001
and December 2008 were used. Descriptive statistics, analysis of variance,
Poisson regression, and simple linear regres¬sion were also used.
Results: In total, 2,555 new cases of NHL were recorded
between January 2001 and December 2008. The region of Riyadh, Saudi Arabia
had the highest overall age-standardized incidence rate (ASIR) at 7.8,
followed by the Eastern region at 6.8, and Makkah at 6.1 per 100,000 men;
however, Jazan, Hail, and Baha had the lowest average ASIRs at 2.5, 3.7, and
3.9 per 100,000 men, respectively. The incidence-rate ratio for the number of
NHL cases was signifi¬cantly higher in Riyadh (4.68, 95% confidence interval
[CI] 4.11–5.32), followed by Makkah (4.47, 95% CI 3.94–5.07), and the Eastern
region of Saudi Arabia (3.27, 95% CI 2.90–3.69) than that in the reference
region of Jazan. Jouf had the highest changes in the ASIRs of NHL among Saudi
men from 2001 and 2008 (5.0 per 100,000 men).
Conclusion: A significant increase in the crude incidence rate
and ASIR for NHL in Saudi Arabia between 2001 and 2008 was found. Riyadh, the
Eastern region, and Makkah had the highest overall ASIR in Saudi Arabia.
Jazan, Hail, and Baha had the lowest rates. Additionally, Riyadh, Makkah, and
the Eastern region had the highest incidence-rate ratio for the number of NHL
cases. Finally, Jouf had the highest changes in crude incidence rate and ASIR
from 2001 to 2008. Further analyti¬cal studies are needed to determine the
potential risk factors of NHL among Saudi men.
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البحث (6):
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عنوان البحث:
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The Incidence Rate of Thyroid Cancer Among
Women in Saudi Arabia: An Observational Descriptive Epidemiological Analysis
of Data from Saudi Cancer Registry 2001–2008
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رابط إلى البحث:
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تاريخ النشر:
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May 2014
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موجز عن البحث:
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This study provides a descriptive
epidemiological data of thyroid cancer cases diagnosed from 2001 to 2008
among Saudi women, including the frequency and percentage of cases, the crude
incidence rate (CIR) and the age-standardised incidence rate (ASIR)
stratified by the region and year of diagnosis. This is a retrospective
descriptive epidemiological analysis of all Saudi thyroid cancer cases
recorded in the Saudi Cancer Registry (SCR) between January 2001 and December
2008. The statistical analyses were applied using descriptive statistics with
the Statistical Package for the Social Sciences version 20.0. A total of
2,930 cases were recorded in the SCR between January 2001 and December 2008.
The region of Riyadh in Saudi Arabia had the highest overall ASIR at 9.43 per
100,000 women, followed by Tabuk at 7.11 and eastern region at 6.5, while
Jazan and Jouf had the lowest average ASIRs at 1.97 and at 2.72,
respectively. The region of Qassim recorded the greatest changes of ASIR at
5.5 per100,000 women from 2001 to 2008. There was a slight increase in the
CIRs and ASIRs for thyroid cancer in Saudi Arabia between 2001 and 2008.
Riyadh, Tabuk and eastern region were the highest overall ASIR in Saudi
Arabia. While, Jazan and Hail had the lowest rates. Finally, the region of
Qassim had the highest changes in CIR and ASIR from 2001 to 2008. Further
analytical studies are needed to determine the potential risk factors of
thyroid cancer disease among Saudi women.
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البحث (7):
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عنوان البحث:
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The incidence of leukemia in Saudi Arabia:
Descriptive epidemiological analysis of data from the Saudi Cancer Registry
(2001-2008)
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رابط إلى البحث:
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تاريخ النشر:
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July 2014
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موجز عن البحث:
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Objectives: To describe
the epidemiological data of leukemia cases diagnosed from 2001 to 2008 among
male and female Saudis, including the frequency and percentage of cases, the
crude incidence rate (CIR), and the age-standardized incidence rate (ASIR)
stratified by leukemia subtype, region, and year of diagnosis.
Methods: This is a
retrospective descriptive epidemiological analysis of all Saudi leukemia
cases recorded in the Saudi Cancer Registry (SCR) between January 2001 and
December 2008. The study was carried out in 2013 to investigate the pattern
of leukemia in the Saudi population. Descriptive statistics and Poisson
regression model were used.
Results: A total of
3852 leukemia cases were registered in the SCR between January 2001 and
December 2008. The region of Riyadh, Saudi Arabia had the highest overall
ASIR among Saudi males at 5.2 per 100,000 males, followed by both the Eastern
region and Northern region at 4.9 per 100,000 males. Furthermore, the region
of Najran recorded the highest overall ASIR among Saudi females at 4.5 per
100,000 females. However, Jazan had the lowest average ASIRs of leukemia in
Saudi Arabia.
Conclusion: There
was a slight increase in the CIRs and ASIRs of leukemia in Saudi Arabia
between 2001 and 2008. Riyadh, the Eastern region, and the Northern region
had the highest overall ASIRs of leukemia among Saudi males, and Najran had
the highest overall ASIRs of leukemia among Saudi females; while Jazan had
the lowest rates among the Saudi population.
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البحث (8):
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عنوان البحث:
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The pattern of Middle East respiratory
syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis
of data from the Saudi Ministry of Health
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رابط إلى البحث:
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تاريخ النشر:
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Aug 2014
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موجز عن البحث:
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Purpose: This study
describes the epidemiology of Middle East respiratory syndrome coronavirus
(MERS-CoV) in Saudi Arabia.
Patients
and methods: Epidemiological analysis was performed on data from all MERS-CoV
cases recorded by the Saudi Ministry of Health between June 6, 2013 and May
14, 2014. The frequency of cases and deaths was calculated and adjusted by
month, sex, age group, and region. The average monthly temperature and
humidity of infected regions throughout the year was also calculated.
Results: A total of
425 cases were recorded over the study period. The highest number of cases
and deaths occurred between April and May 2014. Disease occurrence among men
(260 cases [62%]) was higher than in women (162 cases [38%]), and the case
fatality rate was higher for men (52%) than for women (23%). In addition,
those in the 45–59 years and 60 years age groups were most likely to be
infected, and the case fatality rate for these people was higher than for
other groups. The highest number of cases and deaths were reported in Riyadh
(169 cases; 43 deaths), followed by Jeddah (156 cases; 36 deaths) and the
Eastern Region (24 cases; 22 deaths). The highest case fatality rate was in
the Eastern Region (92%), followed by Medinah (36%) and Najran (33%).
MERS-CoV infection actively causes disease in environments with low relative
humidity (20%) and high temperature (15°C–35°C).
Conclusion:
MERS-CoV is considered an epidemic in Saudi Arabia. The frequency of cases
and deaths is higher among men than women, and those above 45 years of age
are most affected. Low relative humidity and high temperature can enhance the
spread of this disease in the entire population. Further analytical studies
are required to determine the source and mode of infection in Saudi Arabia.
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البحث (9):
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عنوان البحث:
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The
power of the age standardized incidence rate to discover the gene link
between cancer diseases: development of a new epidemiological method to save
money, time, and effort for genetic scientists
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رابط إلى البحث:
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تاريخ النشر:
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31 March
2015
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موجز عن البحث:
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Background: This study provides an incipient epidemiological rule using the
concept of direct method of standardization to determine the genetic link
between cancer diseases.
Methods: The overall 8 or 10 years age standardized incidence rate (ASIR)
for both cancer diseases, for example (A) and (B) should be calculated for
all regions of the country. A line chart should be used to display the
overall ASIR trend of both diseases (A and B). Pearson’s correlation can be
used to determine the strength of the association between the overall ASIRs
of both diseases. The overlap or opposite direction of the overall ASIR trend
of both diseases (A and B) should be determined and studied for possible
associations between cancer diseases.
Results: If the trend of the overall 8 or 10 years ASIR of a disease (A)
follows that of disease (B) in all regions of the country, then the genes of
patients with both diseases (A and B) will be highly homogeneous, and they
should be studied in the region with the highest and lowest overall ASIR for
both diseases (A and B). In addition, if there is an opposite direction or
overlapping trend for both diseases (A and B) in certain regions of the
country or among specific groups of people with the same demographic
characteristics, then the genes of patients will be investigated for both
diseases to identify the potential gene link between cancer diseases.
Conclusion: This study revealed that the overall ASIR
trends of female breast cancer, prostate cancer, and ovarian cancer are very
similar in all regions of Saudi Arabia and England. Our epidemiological
evidence helps to save money, time, and effort for testing the potential gene
link between cancer diseases.
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البحث (10):
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عنوان البحث:
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Early marriage is a potential risk
factor for female breast cancer in the Eastern Region of Saudi Arabia
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رابط إلى البحث:
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here
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تاريخ النشر:
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06/ 2015
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موجز عن البحث:
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This study investigates the
potential risk factors of female breast cancer in the eastern region of Saudi
Arabia. It is a hospital-based case control study of all Saudi women who were
diagnosed with breast cancer during the period from 2010 to 2011. It includes
225 cases and 450 age-matched controls. The statistical analyses were
conducted using descriptive statistics, the Student Sample t-test, the
Mann-Whitney U test, Chi square test and matched logistic regression model.
The factor of early marriage or early sexual intercourse, that is, for
females under 18 years of age (OR = 13.9, 95% CI, 6.0 to 32.3), was the
strongest risk factor for breast cancer among women in the eastern region of
Saudi Arabia; this was followed by the factors of obesity with a high body
mass index (BMI) greater than or equal to 30 (OR = 5.7, 95% CI, 2.53 to
13.0); and prolonged use of birth control pills ≥ 36 months (OR = 5.0, 95%
CI, 2.13 to 11.8). This study concluded that early marriage is the strongest
potential risk factor for female breast cancer among Saudi women. Therefore,
it is recommended to increase family awareness and knowledge about the
suitable age for marriage.
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