مجال
التميز
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تميز دراسي و بحثي
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البحوث المنشورة
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البحث (1):
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عنوان البحث:
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1H, 13C, 15N HMBC, and 19F NMR spectroscopic
characterisation of seized flephedrone, cut with benzocaine
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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29/12/2014
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موجز عن البحث:
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Flephedrone
(4-fluoromethcathinone, 4-FMC) was analysed using 1H, 13C, 15N HMBC, and 19F
observe spectroscopy, gas chromatography-flame ionisation detection (GC-FID),
and electrospray ionisation-mass spectrometry (ESI-MS). Analysis of four
4-FMC samples (from a Bristol nightclub in 2013) showed that they all
contained benzocaine as the cutting agent present in different amounts from 5
to 12%. Using these methods, we successfully differentiated between
flephedrone regioisomers and mephedrone in an analytical method validated for
flephedrone as a substituted cathinone. The data show that these now illegal
cathinone-derived stimulants (highs) are now being cut; users cannot be
certain of the purity of the drug they are taking. Furthermore, there are risks
from the pharmaceutically active cutting agents themselves.
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المؤتمرات العلمية:
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المؤتمر (1):
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عنوان المؤتمر:
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The
Academy of Pharmaceutical Sciences
Conference 2013
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تاريخ الإنعقاد:
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01/09/2013
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مكان
الإنعقاد:
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Edinburgh – UK
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طبيعة المشاركة:
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Poster Presentation
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عنوان المشاركة:
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Fast analytical methods to profile three
seized ketamine samples
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ملخص المشاركة:
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Full
spectroscopic profiling (1H, 13C, FT-IR, UV-Vis, MS-ESI) of three seized
samples of ketamine (KT) were carried out and compared demonstrating that the
three samples are of high purity (>99%), and from their optical rotation
values [α]D20 = 0 (c = 1 mg/mL, MeOH), all three samples are racemic.
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المؤتمر ( 2 ):
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عنوان المؤتمر:
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The Academy of Pharmaceutical Sciences Conference 2013
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تاريخ الإنعقاد:
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02-04/09/2013
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مكان
الإنعقاد:
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Edinburgh – UK
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طبيعة المشاركة:
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Poster Presentation
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عنوان المشاركة:
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Profiling seized samples of mephedrone
adulterated with creatine
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ملخص المشاركة:
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A profile comparison method for the
identification of impurities found in seized mephedrone is reported. Creatine monohydrate was detected in these
samples as an adulterant in high molar ratio (creatine: mephedrone, 3:1 by 1H
NMR integration). Samples were
centrifuged in methanol and submitted to full spectroscopic characterization
(1- and 2D-NMR, FT-IR, ESI-MS).
Possible links between samples, based on their origins, through their
impurities is briefly discussed.
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المؤتمر (3):
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عنوان المؤتمر:
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The Academy of Pharmaceutical Sciences
Conference 2014
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تاريخ الإنعقاد:
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08/09/2014
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مكان
الإنعقاد:
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Hatfield – UK
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طبيعة المشاركة:
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Podium presentation
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عنوان المشاركة:
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Analysis of a Bristol amnesty bin as an
indicator of current drugs trends
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ملخص المشاركة:
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An
amnesty bin was offered by the police at a nightclub in Bristol. On analysis, it was found to contain
different numbers of various illegal drugs.
These were provided as: powders
or crystals in folded paper or plastic bags, tablets, capsules, or as “rocks”
or “bombs” (a twisted cigarette paper).
Legal highs, medicinal and herbal (cannabis) drugs were detected
therein. 1H and 13C NMR spectroscopy
was used as the main analytical technique supported by electrospray
ionisation-mass spectrometry (ESI-MS).
2D NMR (15N, H2BC, HMBC, DEPT) analysis was run in some cases to
provide additional analytical data.
The samples contained drugs from different classes, class A (cocaine,
crack cocaine, ecstasy), class B (mephedrone, flephedrone, cannabis), and
class C (ketamine).
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المؤتمر (4):
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عنوان المؤتمر:
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The Academy of Pharmaceutical Sciences Conference 2014
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تاريخ الإنعقاد:
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08/09/2014
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مكان
الإنعقاد:
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Hatfield – UK
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طبيعة المشاركة:
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Poster Presentation
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عنوان المشاركة:
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Chemical characterisation of seized
flephedrone by 1H, 13C, and 19F NMR spectroscopy
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ملخص المشاركة:
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The
identification of fluorine-containing drugs and their metabolites can
potentially be achieved using NMR spectroscopic analysis. Pharmaceutical analysis of flephedrone
(4-fluoromethcathinone, 4-FMC) included 1H, 13C, 19F, 15N HMBC, and 15N HSQC
spectroscopy and electrospray ionisation-mass spectrometry (ESI-MS). Analysis of four 4-FMC samples (obtained
from a nightclub in 2013) showed that they all contained benzocaine as a
cutting agent, used in different amounts from 7-13%.
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المؤتمر (5):
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عنوان المؤتمر:
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The Academy of Pharmaceutical Sciences Conference 2015
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تاريخ الإنعقاد:
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07-09/09/2015
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مكان
الإنعقاد:
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Nottingham – UK
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طبيعة المشاركة:
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Oral
Presentation
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عنوان المشاركة:
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Carbon and nitrogen stable isotope ratio
analysis of seized and amnesty bin ketamine Samples to determine their
geographical origin
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ملخص المشاركة:
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The
anaesthetic ketamine is abused for its dissociative effects resulting in it
being a controlled drug. There is a
need to determine the sources of abused ketamine, in particular whether it is
being diverted from legitimate veterinary and clinical supplies or
manufactured abroad and imported illegally.
Element analysis by isotopic ratio mass (EA-IRMS) was employed to help
answer this question. Therefore, the
isotopic ratio values of 11 street samples were compared with the available
pharmaceutical products, VetalarTMV and Ketalar®, as well as an authentic
ketamine HCl sample purchased from Sigma Aldrich.
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المؤتمر (6):
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عنوان المؤتمر:
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The
Academy of Pharmaceutical Sciences
Conference 2015
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تاريخ الإنعقاد:
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07-09/09/2015
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مكان
الإنعقاد:
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Nottingham
– UK
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طبيعة المشاركة:
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Poster
Presentation
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عنوان المشاركة:
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Chemical
profiling of MDMA samples and their impurities within a clinical study on
psychoactive effects of MDMA on users
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ملخص المشاركة:
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The
seventeen samples, provided by the study participants, were not of
pharmaceutical grade and while they were believed to contain MDMA (ecstasy)
this needed to be confirmed authoritatively as part of a clinical study into
the unique sociotropic effects of MDMA.
In order to identify the components of the samples, in particular, to
determine if other psychoactive substances were present, the crystalline
samples were subjected to Ultra Performance Liquid Chromatography-tandem Mass
Spectrometry (UPLC/MS/MS) and detailed Nuclear Magnetic Resonance (NMR)
analysis.
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المؤتمر (7):
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عنوان المؤتمر:
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The
Academy of Pharmaceutical Sciences
Conference 2015
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تاريخ الإنعقاد:
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07-09/09/2015
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مكان
الإنعقاد:
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Nottingham
– UK
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طبيعة المشاركة:
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Poster
Presentation
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عنوان المشاركة:
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Impurity
profiling of seized and amnesty bin ketamine samples to determine if any
diversion from hospital or veterinary sources to drug users in the UK
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ملخص المشاركة:
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Anaesthetic
ketamine B.P. is now also known as a drug of abuse. Pharmaceutical products VetalarTMV and
Ketalar® were analysed by spectroscopic profiling (1H and 13C NMR, [α]D20,
ESI-MS and UPLC/MS/MS) together with many seized and amnesty bin samples of
ketamine. It is likely that the drug
being abused is synthetic rather than diverted B.P. samples due to the
absence of any preservative.
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المؤتمر (8):
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عنوان المؤتمر:
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4th International Conference on Forensic Research &
Technology
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تاريخ الإنعقاد:
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28-30/09/2015
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مكان
الإنعقاد:
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Atlanta,
USA
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طبيعة المشاركة:
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Oral
Presentation
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عنوان المشاركة:
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To
determine the geographical origin of street ketamine samples by using 13C and
15N stable isotope ratio analysis
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ملخص المشاركة:
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The
anaesthetic ketamine is abused for its dissociative effects resulting in it
being a controlled substance. There is a need to determine the sources of the
abused ketamine, in particular whether it is being diverted from legitimate
veterinary and clinical supplies or manufactured abroad and imported
illegally. Element analysis by isotopic ratio was employed to help answer
this question. Therefore, the isotopic ratio values of 11 street samples were
compared with the available ketamine pharmaceutical products, VetalarTMV and
Ketalar®, as well as an authentic ketamine HCl sample purchased from Sigma
Aldrich. This study shows the
feasibility of using δ13C‰ and δ15N‰ values to link or discriminate between
various ketamine samples. None of the illicit samples had isotopic ratio
fingerprints equivalent (or even similar) to the VetalarTMV and Ketalar®
samples, suggesting they had not been diverted from veterinary or hospital
supplies, nor purchased from Sigma-Aldrich.
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المؤتمر (9):
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عنوان المؤتمر:
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23rd Congress of the International Academy of Legal
Medicine (IALM)
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تاريخ الإنعقاد:
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19-21/01/2015
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مكان
الإنعقاد:
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Dubai
– UAE
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طبيعة المشاركة:
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Poster
Presentation
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عنوان المشاركة:
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Analysis Of
A Bristol Amnesty Bin As An Indicator Of Current Drugs Trends
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ملخص المشاركة:
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Amnesty
bin analysis can provide potential information about currently abused drugs
and possibly about such drug availability.
One aim of this study is therefore to elicit any trends in such drug
abuse, and then to corroborate them with regional data to provide better
intelligence for police drug control.
Drug formulation may determine the route of administration e.g. a
freebase is likely to be smoked, whilst the salt form is mostly administered
as an injection or drunk if mixed with alcohol. Despite emerging concerns over new
psychoactive substances (NPS), class A drugs are still available. These analytical results show the
application of NMR spectroscopy in drug detection with no need for sample
preparation, reference material, or internal standard.
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المؤتمر (10):
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عنوان المؤتمر:
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23rd
Congress of the International Academy of Legal Medicine (IALM)
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تاريخ الإنعقاد:
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19 – 21/01/2015
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مكان
الإنعقاد:
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Dubai
– UAE
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طبيعة المشاركة:
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Poster
Presentation
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عنوان المشاركة:
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Chemical
Characterisation Of Seized Flephedrone By 1H, 13C, 15N Hmbc, And 19F Nmr
Spectroscopy
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ملخص المشاركة:
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Flephedrone
(4-fluoromethcathinone, 4-FMC) was analysed using 1H,13C, 15N HMBC, and 19F
observe spectroscopy, Gas-Chromatography Flame Ionisation Detection (GC-FID),
and Electrospray Ionisation-Mass Spectrometry (ESI-MS). Analysis of four
4-FMC samples showed that they all contained benzocaine as the cutting agent present
in different amounts from 5-12%. Using these methods, we successfully differentiated
between flephedrone regioisomers and mephedrone in an analytical method
validated for flephedrone as a substituted cathinone. The data show that
these now illegal cathinone-derived stimulants (highs) are now being cut and
users cannot be certain of the purity of the drug they are taking.
Furthermore, there are risks from the pharmaceutically active cutting agents
themselves.
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