مجال
التميز
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تميز
دراسي و بحثي + جائزة تفوقية
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البحوث المنشورة
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البحث (1):
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عنوان البحث:
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Microbial Endocrinology: Host-Bacteria Communication
Within The Gut Microbiome
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رابط إلى البحث:
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Click here
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تاريخ النشر:
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19/03/2015
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موجز عن البحث:
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The human body is home to trillions of micro-organisms,
which are increasingly being shown to have significant effects on a variety
of disease states. Evidence exists that a bidirectional communication is
taking place between us and our microbiome co-habitants, and that this
dialogue is capable of influencing our health in a variety of ways. This
review considers how host hormonal signals shape the microbiome, and what in
return the microbiome residents may be signalling to their hosts.
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المؤتمرات العلمية:
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المؤتمر (1):
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عنوان المؤتمر:
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8th Saudi Students’ Conference
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تاريخ الإنعقاد:
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31/01-01/02/2015
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مكان
الإنعقاد:
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London,
UK
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طبيعة المشاركة:
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Poster
presentation
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عنوان المشاركة:
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How Can We Protect Peritoneal Dialysis Patients
From Developing Peritonitis?
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ملخص المشاركة:
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Peritoneal
dialysis (PD) is the simplest and most economical renal dialysis technique in
use as a treatment for kidney failure patients. PD is a process that uses the
peritoneum a membrane through which exchange of solutes and fluid can occur
between blood and the dialysis solution, which is infused in to the
peritoneal cavity through a permanent catheter. However, because PD involves repeated and
daily administration of large volumes of dialysis solution into the sterile
peritoneal cavity, this form of dialysis has two major clinical
complications: protein loss and infection leading to peritonitis, a
life-threatening complication. While there has been intensive aseptic
technique education of medical staff and patients, the factors that
predispose PD patients to the development of peritonitis are still not fully
understood. This research project aims to discover the infection-related
protein(s) in peritoneal dialysis fluid (PDF) that predispose patients to
peritonitis, and if successful could result in a much needed prognostic test
to identify those patients at risk of infection. Work from my project so far
suggests that there is a correlation between the levels of total protein or
specific proteins present in the peritoneal dialysis fluid (PDF) and the stimulation
of growth, virulence and toxicity of bacteria that typically cause
peritonitis. It is therefore important to determine the identity of the PDF
infection-risk biomarker(s), so that a simple test for identifying those
patients vulnerable to peritoneal infection can be developed. In the work
described in this poster, the molecular components of the PDF from a range of
peritoneal dialysis patients are analysed, and the patient peritoneal fluids
and their components investigated for their ability to modulate the growth,
virulence and toxicity of peritonitis-causing bacteria. The results presented
point towards the identity of the proteins that might be
infection-risk-associated, and suggestions are made that could lead to
improvements in patient care.
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المؤتمر (2):
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عنوان المؤتمر:
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9th International Conference on Dialysis and Renal
Care
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تاريخ الإنعقاد:
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18/08/2016
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مكان
الإنعقاد:
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London,
UK
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طبيعة المشاركة:
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Paper
presentation
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عنوان المشاركة:
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Risk Factors For The Development Of Peritonitis
In Peritoneal Dialysis Patients
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ملخص المشاركة:
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Peritoneal
dialysis (PD) is the simplest and most economical treatment for renal failure
patients. Nevertheless, the prevalence of this treatment is low worldwide due
to its potential complications, which mainly include protein loss and
peritonitis. Peritonitis is a clinically significant condition that
contributes to the high mortality and morbidity rates observed in PD
patients. Intensive medical staff and patient education, as well as advanced
improvements in aseptic techniques, have recently been introduced, but the
factors that predispose PD patients to peritonitis are still not fully
understood. The overall objective of this research was to analyse the
components of peritoneal dialysis fluids (PDFs) for the presence of protein
and (hormonal factors) that might boost susceptibility to infection. Clinical
samples included initial and follow-up PDF samples collected from nine renal
failure patients. Intra and inter patient proteomic profiling showed
significant variations in the total/type of protein lost into the PDF.
Molecular components of the PDFs such as catecholamines (which we showed for
the very first time were present in PDF) were also investigated for their
ability to modulate the growth and virulence of peritonitis-causing bacteria.
The results pointed towards the identity of the factors that might be
infection-risk-associated as being serum transferrin, which was found to be
significantly more iron saturated than in the blood. Use of radioactive iron-labelled
transferrin showed it could act as a direct iron source for
peritonitis-causing bacteria. We use our data to provide anti-infection
suggestions that could lead to improvements in PD patient care.
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المؤتمر (3):
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عنوان المؤتمر:
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UCL
Infection, Immunology And Inflammation (III) Symposium 2016
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تاريخ الإنعقاد:
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08/11/2016
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مكان
الإنعقاد:
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London,
UK
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طبيعة المشاركة:
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Poster
presentation
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عنوان المشاركة:
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Risk Factors For The Development Of Infectious
Peritonitis In Peritoneal Dialysis Patients
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ملخص المشاركة:
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Peritoneal
dialysis (PD) is the simplest and most economical treatment for renal failure
patients. However, the prevalence of this treatment remains low worldwide
because of its potential complications, which primarily include protein loss
and infectious peritonitis. The latter complication, in particular, is a
clinically significant condition that contributes to the high mortality and
morbidity rates observed in PD patients. Intensive medical staff and patient
education, as well as advanced improvements in aseptic techniques, have
recently been introduced, but the factors that predispose PD patients to
infectious peritonitis are still not fully understood. Therefore, we
investigated the components of peritoneal dialysis fluid (PDF) for the presence
of protein and hormonal factors that might increase PD patient susceptibility
to infection. By using PDF samples obtained from a range of follow-up PD
patients, we showed significant variations in the total/type of protein lost.
Hormonal components of the PDF samples, such as catecholamine stress hormones
(noradrenaline and adrenaline), were also shown for the first time to be
present in PDF samples and found to be involved in modulating the growth of
peritonitis-causing bacteria. The proteomic results identified serum
transferrin as being infection-risk-associated as it was discovered to be
significantly more iron-saturated than transferrin in the blood, while the
use of radioactive iron-labelled transferrin showed that it could act as a
direct iron source for peritonitis-causing bacteria. Based on these and other
results, we present in our data anti-infection suggestions that could lead to
improvements in PD patient care.
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جوائز التكريم:
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الجائزة (1):
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مسمى الجائزة:
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Commendation
For Excellent Quality Of Research Presentation At Postgraduate Conference
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الجهة المانحة:
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University of
Leicester
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تاريخ الجائزة:
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April
2014
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مجال التكريم:
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Developing
a prognostic test for risk of infectious peritonitis in peritoneal dialysis
patients
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