|مجال التميز||تميز دراسي وبحثي|
Behavioural performance improvement in visuomotor learning correlates with functional and microstructural brain changes
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A better understanding of practice-induced functional and structural changes in our brains can help us design more effective learning environments that provide better outcomes. Although there is growing evidence from human neuroimaging that experience-dependent brain plasticity is expressed in measurable brain changes that are correlated with behavioural performance, the relationship between behavioural performance and structural or functional brain changes, and particularly the time course of these changes, is not well characterised.
To understand the link between neuroplastic changes and behavioural performance, 15 healthy participants in this study followed a systematic eye movement training programme for 30 min daily at home, 5 days a week and for 6 consecutive weeks. Behavioural performance statistics and eye tracking data were captured throughout the training period to evaluate learning outcomes. Imaging data (DTI and fMRI) were collected at baseline, after two and six weeks of continuous training, and four weeks after training ended.
Participants showed significant improvements in behavioural performance (faster task completion time, lower fixation number and fixation duration).
Spatially overlapping reductions in microstructural diffusivity measures (MD, AD and RD) and functional activation increases (BOLD signal) were observed in two main areas: extrastriate visual cortex (V3d) and the frontal part of the cerebellum/Fastigial Oculomotor Region (FOR), which are both involved in visual processing. An increase of functional activity was also recorded in the right frontal eye field.
Behavioural, structural and functional changes were correlated. Microstructural change is a better predictor for long-term behavioural change than functional activation is, whereas the latter is superior in predicting instantaneous performance. Structural and functional measures at week 2 of the training programme also predict performance at week 6 and 10, which suggests that imaging data at an early stage of training may be useful in optimising practice environments or rehabilitative training programmes.
The 41st European Conference on Visual Perception (ECVP 2018)
|مكان الإنعقاد:||Trieste, Italy|
|طبيعة المشاركة:||Oral Presentation|
|عنوان المشاركة:||Systematic eye movement training to predict the outcome from neuroimaging data at the initial stage of stroke treatment|
A better understanding of structural and functional brain changes may optimise post stroke treatment. The aim of this study is to predict treatment outcome early from functional and structural neuroimaging data in hemianopia patients following visual scanning training.
Here we report on an initial study of 15 healthy participants (aged 20-60) who followed a systematic visual scanning training for 30 minutes daily, 5 days a week and for 6 consecutive weeks. The training involved eye scanning out to 20 degrees each side of central fixation to locate visual targets in peripheral vision.
Participants showed significant improvements in behavioural performance (lower task completion time and fixation number).
Significant functional change is seen in visual cortex V3d. Additionally, we show selective activation in Brodmann area 9 (Superior Frontal Gyrus) for predictive eye movement saccades, but not in reflexive saccades. This area also showed increased functional activation during training.
|عنوان المؤتمر:||Liverpool Neuroscience Group (LND2018)|
|تاريخ الإنعقاد:||Liverpool, UK|
|طبيعة المشاركة:||Poster presentation|
|عنوان المشاركة:||Systematic eye movement training to predict the outcome of stroke rehabilitation from neuroimaging data at the initial stage of stork treatment|
|ملخص المشاركة:||A better understanding of the impact of learning on functional or structural brain changes may optimise post stroke treatment. The aim of this study is to predict treatment outcome early from neuroimaging data which are associated with behavioural performance in hemianopia patients following visual scanning training. Here we report on an initial study of 15 healthy participants (aged 20-60) who followed a systematic visual scanning training. Participants showed significant improvements in behavioural performance and significant functional change in visual cortex. Selective activation in Brodmann area is seen.|