مجال التميز | تميز دراسي وبحثي + جائزة تفوقية |
البحوث المنشورة |
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البحث (1): | |
عنوان البحث: |
Scoping review of trials evaluating adhesive strategies in paediatric dentistry: where do simplified strategies lie? |
رابط إلى البحث: | |
تاريخ النشر: |
19/01/2021 |
موجز عن البحث: |
Background: Adhesive restorations allow a conservative approach to caries management and are increasingly used as a restorative option in paediatric dentistry. Placement can be difficult in children because of the cooperation required for multiple bonding steps. Due to this, it is vital to assess if novel, simpler strategies have been featured in clinical trials and if clinical trials are researching the different existing adhesive strategies. Methods: This review followed Preferred Reporting Items for Systematic Reviews and Meta-analysis adapted for Scoping Reviews (PRISMA-ScR) guidelines. PubMed/Medline, Cochrane Central, Scopus and EMBASE were used for systematic search, using free keywords and controlled search terms. Clinical trials of children requiring a restorative intervention which featured adhesive strategies were included. Only peer-reviewed trials of primary teeth restored with resin composites, published in the last 10-year period were eligible. Data charting was accomplished independently by two reviewers, and studies were summarized according to their date, type, intervention, sample size, observation period, outcomes, and conclusions. Quality assessment was performed using Cochrane’s Risk of Bias 2.0 tool. Results: 700 potentially relevant references were found, which after a rigorous inclusion scheme, resulted in a total of 8 eligible clinical trials. Out of these, 7 were randomized clinical trials. Most trials featured a split-mouth design and the observation period ranged from 12 to 36 months. The trials evaluated interventions of two self-adhesive composites, two bulk-fll composites, two novel composites, one compomer and eight adhesives from different strategies. Most studies (4/8) included were judged to raise some concerns regarding risk of bias, while two were classified as high risk and two as low. Conclusion: Few studies comparing adhesive strategies were found, especially adhesives in sound substrates. The existing studies do not reflect all current approaches that could be used in paediatric dentistry. Further studies addressing bioactive composites and contemporary adhesives are necessary. |
البحث (2): | |
عنوان البحث: |
Integration of Regenerative Dentistry Into the Dental Undergraduate Curriculum |
رابط إلى البحث: | |
تاريخ النشر: |
10/11/2020 |
موجز عن البحث: |
Rapid scientific advances continue to contribute to novel therapies and technologies, many of which have the potential to transform dentistry. Regenerative medicine can be regarded as a multidisciplinary field encompassing molecular biology, genetics, tissue engineering, and nanotechnology that has been successfully integrated into different clinical disciplines over the last 20 years. Regenerative dentistry focuses on the regeneration of soft and hard tissues by incorporating tissue engineering approaches. It has been defined as “an interdisciplinary field that applies the principles of both engineering and life sciences, toward the development of biological substitutes that restore, maintain, or improve tissue function. In dentistry, regenerative therapies are often thought of as a future, rather than a current, modality. However, dentists have been using regenerative therapies for decades, one example being vital pulp therapy. In this piece different aspect will be discussed regarding regenerative dentistry and the aim of integrating it in the curriculum of dental undergraduates. |
البحث (3): | |
عنوان البحث: |
Molar Incisor Hypomineralisation—To Extract or to Restore beyond the Optimal Age? |
رابط إلى البحث: | |
تاريخ النشر: |
06/08/2020 |
موجز عن البحث: |
The management of compromised first permanent molars (FPMs) in children presents a clinical challenge to the dental team. Hypomineralised FPMs in molar incisor hypomineralisation (MIH) conditions could undergo post-eruptive breakdown, making them susceptible to caries, leading to their subsequent loss. The planned extraction of compromised FPMs is a valid alternative to complex restorative treatment. However, establishing the presence or absence of third permanent molars, amongst other considerations, is crucial to reaching a successful outcome. Clinicians should understand the importance of an orthodontic examination around the age of 8 years old with regard to establishing a differential therapeutic decision about the ideal timing of MIH-affected FPMs’ extraction in children. The aim of this article is to highlight that, with an interdisciplinary approach, a good outcome can be achieved following the extraction of poorly prognosed FPMs. The most cost-effective way of addressing MIH-affected FPMs is extraction, followed by orthodontic space closure when indicated. This obviates the need for the repeated restorative replacement and saves perfectly healthy premolars from being extracted for space creation in orthodontic treatment in several clinical scenarios. |
المؤتمرات العلمية |
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المؤتمر (1): | |
عنوان المؤتمر: |
DLS5 Bahrain Dental Conference & Exhibition |
تاريخ الإنعقاد: |
4-8/11/2020 |
مكان الإنعقاد: |
Bahrain (virtual) |
طبيعة المشاركة: |
E-Poster |
عنوان المشاركة: |
Inhibition of Matrix Metalloproteinase Activity via a Novel SMART Composite Versus Commercial Filling Materials |
ملخص المشاركة: |
Objectives: This study aimed to quantifies MMP activity at the surface of demineralised dentine following sealing by a new SMART composite versus commercially available restorative materials. Methods: 2mm thick sections of coronal dentine from sound human molars, obtained following ethical approval, were fully demineralised through immersion in 4M formic acid for 48 hours. Following application of a green fluorescent probe (EnzCheck Collagenase Assay Kit) for 5 minutes, restorative materials were applied on one surface. Materials included SMART (Schottlander), 3M ESPE Filtek Z250, ACTIVA KIDS Bioactive compomer OptiBond Solo Plus adhesive and GC Fuji IX, GIC according to the manufacturer’s instructions. Non-restored dentine was used as control. Samples were stored in deionised water and incubated at 37oC. Following 1 or 14 days, samples (n=4) were sectioned, and the interface area imaged using Confocal Light Scanning Microscopy (CLSM)(Fig.1). The percentage area of green fluorescence in sections 260×260μm² MMP activity was determined through ImageJ. Results: Example CLSM images are shown in Figure 2, and the percentage areas that are green in Figure 3. SMART restoration had the least fluorescence initially (0.5%), which after 14 days almost totally disappeared. Z250 and ACTIVA results were similar after incubation at day 1 (2.5%-2.0%) and day 14 (2.0% 1.8%) respectively. MMP activity of GIC (Fuji lX) was lower than Z250 and ACTIVA on day 1; however, it was significantly higher at day 14, reaching 3.5%. Conclusion: Sealing of demineralized dentine by SMART composite substantially reduced the collagen fibril degrading MMP enzyme activity. We have shown that the novel SMART composite can be an effective option to be added in the toolkit of dentists for restoring carious teeth. |
الرابط: | |
المؤتمر (2): | |
عنوان المؤتمر: |
IAPD20 Virtual |
تاريخ الإنعقاد: |
13-17/09/2020 |
مكان الإنعقاد: |
UK (virtual) |
طبيعة المشاركة: |
Poster presentation |
عنوان المشاركة: |
Inhibition of Matrix Metalloproteinase Activity via a Novel SMART Composite Versus Commercial Filling Materials |
ملخص المشاركة: |
Objectives: This study aimed to quantifies MMP activity at the surface of demineralised dentine following sealing by a new SMART composite versus commercially available restorative materials. Methods: 2mm thick sections of coronal dentine from sound human molars, obtained following ethical approval, were fully demineralised through immersion in 4M formic acid for 48 hours. Following application of a green fluorescent probe (EnzCheck Collagenase Assay Kit) for 5 minutes, restorative materials were applied on one surface. Materials included SMART (Schottlander), 3M ESPE Filtek Z250, ACTIVA KIDS Bioactive compomer OptiBond Solo Plus adhesive and GC Fuji IX, GIC according to the manufacturer’s instructions. Non-restored dentine was used as control. Samples were stored in deionised water and incubated at 37oC. Following 1 or 14 days, samples (n=4) were sectioned, and the interface area imaged using Confocal Light Scanning Microscopy (CLSM)(Fig.1). The percentage area of green fluorescence in sections 260×260μm² MMP activity was determined through ImageJ. Results: Example CLSM images are shown in Figure 2, and the percentage areas that are green in Figure 3. SMART restoration had the least fluorescence initially (0.5%), which after 14 days almost totally disappeared. Z250 and ACTIVA results were similar after incubation at day 1 (2.5%-2.0%) and day 14 (2.0% 1.8%) respectively. MMP activity of GIC (Fuji lX) was lower than Z250 and ACTIVA on day 1; however, it was significantly higher at day 14, reaching 3.5%. Conclusion: Sealing of demineralized dentine by SMART composite substantially reduced the collagen fibril degrading MMP enzyme activity. We have shown that the novel SMART composite can be an effective option to be added in the toolkit of dentists for restoring carious teeth. |
الرابط: | |
جوائز التكريم |
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الجائزة (1): | |
مسمى الجائزة: |
DLS5 Bahrain Virtual Competition Awards “Live E-Posters Meeting” |
الجهة المانحة: |
DLS5 Bahrain Dental Conference & Exhibition in collaboration with IADR Saudi Arabian Division committee |
تاريخ منح الجائزة: |
04/11/2020 |
مجال التكريم: |
1st Place winner in the poster virtual conference for the paper entitled: “Inhibition of Matrix Metalloproteinase Activity via a Novel SMART Composite Versus Commercial Filling Materials” |
الرابط: |
حسن محمدعلي حسن جمال
دكتوراه
الطب والخدمات الصحية
UCL – University of London