مجال التميز | تميز دراسي وبحثي |
البحوث المنشورة |
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البحث (1): |
نشر فصل في كتاب بعنوان: New Frontiers in Medicine and Medical Research |
عنوان الفصل: |
Epidemiology of Prostate Cancer in Saudi Arabia |
رابط إلى الفصل: | |
تاريخ النشر: |
21/08/2021 |
موجز عن الفصل: |
Problem identification: Prostate Cancer and its prevalence worldwide have increased over the past several years as the knowledge and methods for early detection of cancer have been improving. Prostate Cancer is also considered to be the second most common cancer in Middle Eastern countries, and is ranked as the sixth leading cause of mortality among men. This study aims to identify the role of genetics and environmental factors in the development and progression of Prostate Cancer among Middle Eastern countries, with focus on the prevalence and mortality of Prostate Cancer in Saudi Arabia. The study also aims to examine proposed risk factors for the development of Prostate Cancer among Middle Eastern men. Literature search: Extensive literature search was made to find articles and studies regarding to the prevalence of Prostate Cancer in Saudi Arabia, and the potential reasons for its increased prevalence over the years. Studies about the established and proposed risk factors contributing to the development of Prostate Cancer was also included in the literature search. Conclusion: Results of literature reviewed and studied in this paper showed that genetics and individual anatomy of Arab men are of importance in the development of Prostate Cancer. For environmental causes, it was identified that the changing lifestyle of Arab men, and becoming more open to Western influence also contributed to the prevalence of Prostate Cancer. It was also found out that with the improving status of the medical practices in Saudi Arabia, it is expected that more cases are to be detected, as more access will be rendered available to the citizens for the immediate detection of Prostate Cancer. |
البحث (2): | |
عنوان البحث: |
atty acid-binding protein 5 (FABP5)-related signal transduction pathway in castration-resistant prostate cancer cells: a potential therapeutic target |
رابط إلى البحث: |
https://academic.oup.com/pcm/article/2/3/192/5565426?login=true |
تاريخ النشر: |
09/09/2019 |
موجز عن البحث: |
In this short communication, a novel fatty acid-binding protein 5 (FABP5)-related signal transduction pathway in prostate cancer is reviewed. In castration-resistant prostate cancer (CRPC) cells, the FABP5-related signal transduction pathway plays an important role during transformation of the cancer cells from androgen-dependent state to androgen-independent state. The detailed route of this signal transduction pathway can be described as follows: when FABP5 expression is increased as the increasing malignancy, excessive amounts of fatty acids from intra- and extra-cellular sources are transported into the nucleus of the cancer cells where they act as signalling molecules to stimulate their nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). The phosphorylated or biologically activated PPARγ then modulates the expression of its downstream target regulatory genes to trigger a series of molecular events that eventually lead to enhanced tumour expansion and aggressiveness caused by an overgrowth of the cancer cells with a reduced apoptosis and an increased angiogenesis. Suppressing the FABP5-related pathway via RNA interference against FABP5 has produced a 63-fold reduction in the average size of the tumours developed from CRPC cells in nude mice, a seven-fold reduction of tumour incidence, and a 100% reduction of metastasis rate. Experimental treatments of CRPC with novel FABP5 inhibitors have successfully inhibited the malignant progression of CRPC cells both in vitro and in nude mouse. These studies suggest that FABP5-related signal transduction pathway is a novel target for therapeutic intervention of CRPC cells. |
سعود عبدالصمد محمد عبدالصمد
دكتوراه
الطب والخدمات الصحية
University of Liverpool