مجال التميز | تميز دراسي و بحثي |
البحوث المنشورة |
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البحث (1): | |
عنوان البحث: |
Biomphalaria pfeifferi Snails and Intestinal Schistosomiasis, Lake Malawi, Africa, 2017-2018 |
رابط إلى البحث: | |
تاريخ النشر: |
03/2019 |
موجز عن البحث: |
Two surveys conducted in 2017 and 2018 demonstrated Biomphalaria pfeifferi snails in Lake Malawi in Africa. Epidemiologic examination of 175 local children at 3 primary schools confirmed emergence of intestinal schistosomiasis. These findings highlight autochthonous transmission of Schistosoma mansoni flukes in Lake Malawi and the need to revise international travel advice. |
البحث (2): | |
عنوان البحث: |
Schistosome Interactions within the Schistosoma haematobium Group, Malawi |
رابط إلى البحث: | |
تاريخ النشر: |
06/06/2019 |
موجز عن البحث: |
Molecular analysis of atypical schistosome eggs retrieved from children in Malawi revealed genetic interactions occurring between human (Schistosoma haematobium) and livestock (S. mattheei and S. bovis) schistosome species. Detection of hybrid schistosomes adds a notable new perspective to the epidemiology and control of urogenital schistosomiasis in central Africa. |
المؤتمرات العلمية |
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المؤتمر (1): | |
عنوان المؤتمر: |
BSP Spring Meeting 2019 meeting |
تاريخ الإنعقاد: |
15-17/04/2019 |
مكان الإنعقاد: |
Manchester. UK |
طبيعة المشاركة: |
Poster presentation |
عنوان المشاركة: |
First report of Biomphalaria pfeifferi in Lake Malawi, Mangochi District with emergence of intestinal schistosomiasis in local primary school children |
ملخص المشاركة: |
Autochthonous transmission of Schistosoma mansoni in Lake Malawi which is of particular concern for nationals as well as travellers. The full report can be found in the March edition of Emerging Infectious Diseases https://wwwnc.cdc.gov/eid/article/25/3/18-1601_article and associated blog http://blogs.biomedcentral.com/bugbitten/. In November 2017, upon inspection of 14 sampling sites within Lake Malawi, Mangochi District, Biomphalaria pfeifferi was found at 2 sampling locations. Snail species identity was confirmed with molecular DNA analysis of the mitochondrial cytochrome oxidase sub-unit 1 (cox1) gene. In May 2018, an additional 43 sites were surveyed, finding this species in a total of 10 locations. To ascertain if intestinal schistosomiasis was also locally present, 175 school children from three primary schools, close to known Biomphalaria sites were examined. At each school, the prevalence of intestinal schistosomiasis by circulating cathodic antigen (CCA) urine-dipsticks was 46.7%, 25.0% and 9.1%, respectively. Egg-patent infections of Schistosoma mansoni were confirmed by faecal microscopy. |
المؤتمر (2): | |
عنوان المؤتمر: |
13th International Symposium on Geospatial Health |
تاريخ الإنعقاد: | 16/09/2019 |
مكان الإنعقاد: |
Liverpool.UK |
طبيعة المشاركة: |
Paper presentation |
عنوان المشاركة: |
Documenting Biomphalaria pfeifferi along Lake Malawi, Mangochi District shorelines |
ملخص المشاركة: |
Whilst the freshwater snail fauna of Lake Malawi is well-known to sustain local transmission of urogenital schistosomiasis, it was assumed, until recently, unable to sustain transmission of intestinal schistosomiasis. Upon malacological surveys conducted in November 2017, whilst Bulinus was commonly found, Biomphalaria was unexpectedly encountered in two sampling sites on the western shoreline of Mangochi District. Collected Biomphalaria snails were characterized by molecular DNA analysis of the mitochondrial cytochrome oxidase sub-unit 1 (COI) gene, inferring a genetic lineage of Bi. pfeifferi likely originating from nearby Zimbabwe. During a second malacological survey in May 2018, with additional sites surveyed, Bi. pfeifferi was found at 9 further locations, with its presence re-confirmed at a previously sampled location. One year later, a third malacological survey also confirmed B. pfeifferi on the western, and now eastern shorelines of Mangochi District. Collectively, these malacological surveys have confirmed the sustained presence of B. pfeifferi within Lake Malawi, adding to its list of endemic species. Our findings are of significant medical interest, since our recent parasitological surveys of school children have confirmed intestinal schistosomiasis. This raises concerns for local health authorities and tourists to this part of the lake for autochthonous transmission of intestinal schistosomiasis. Moreover our studies serve as excellent examples of how routine malacological surveillance can shed new light on the changing epidemiology of schistosomiasis in Lake Malawi. |
الرابط: | Link |
محمد حجاج حضيرم الحربي
دكتوراه
الطب والخدمات الصحية
University of Liverpool